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siRNA Drug Development Program


Bioneer's siRNA Drug Development Program using SAMiRNA Technology

Vertically integrated processes within Bioneer's siRNA Drug Development Program provide a total solution for siRNA therapeutics discovery and development, from siRNA design/synthesis and preclinical tests to IND filing. With its world's-best RNAi core technologies and manufacturing infrastructure, Bioneer is the ideal partner for pharmaceutical and biotechnology companies currently working on the development of RNAi therapeutics, or seeking to enter the RNAi field. Bioneer's research and technical support teams ensure top-quality products and services to meet your unique needs.


Our siRNA Drug Development Program includes:

- Design and synthesis of siRNAs (custom siRNA synthesis using patented design algorithm, which has
  been used for genome-wide siRNA libraries for human, mouse and rat)
- in vitro screening and validation of siRNAs including MIQE qPCR analysis of knockdown rates
- Preclinical test using SAMiRNA including in vivo siRNA delivery and biodistribution/efficacy test using
  murine and non-human primate models
- Large scale manufacturing of SAMiRNA (in house raw material manufacturing facilities, fully automated
  siRNA/SAMiRNA synthesis pipeline)
- Drug candidates efficacy/toxicity tests in nonhuman primate (through collaboration with Korea Institute
  of Toxicology)


Please see below our siRNA core technologies and siRNA Drug Development Program Roadmap





Please click each step for more information