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1) 항 비만(체지방)

모든 지방세포에서 일반식이군에 비해 고지방식이군의 지방세포 크기가 유의적으로 증가된 것으로 나타났으며, Lb. gasseri BNR17 투여군에서는 고지방식이군에 비해 유의적으로 감소하였고. 이들 지방 조직의 세포 크기를 비교할 때 동일한 면적내에 보여지는 지방 세포의 크기를 측정하였기 때문에, Lb. gasseri BNR17 투여에 인해 지방 세포 크기가 작다는 것은 BNR17이 체지방 축적을 억제하여 지방 세포의 hypertrophy를 억제확인.


-체중 감소가 식이섭취량이 아닌 Lb. gasseri BNR17 로 확인

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Figure 1. Change in body weight of C57BL/6J mice administered with ND, HSD or HSD containing Lb. gasseri BNR17 (109 CFU or 1010 CFU) for 10 weeks. Data are means ± SD. pairwise t test. * P < 0.05, ** P < 0.01, *** P < 0.001 versus HSD group.


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Figure 2. Change in food intake of C57BL/6J mice administered with ND, HSD or HSD containing Lb. gasseri BNR17(109 CFU or 1010 CFU) for 10 weeks. Data are means ± SD. pairwise t test. ### P < 0.001 versus HSD group.


-Lb. gasseri BNR17을 투여한 군에서 피하 지방 및 내장 지방이 감소

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Figure 3. Representative CT scanning images of abdominal (left) and whole body (right) fat accumulation (in black) C57BL/6J mice.


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Figure 4. Fat volume of subcutaneous and abdominal fat of C57BL/6J mice administered with ND, HSD or HSD containing Lb. gasseri BNR17 (109 CFU or 1010 CFU) for 10 weeks. Data are means ± SD. pairwise t test. *** P < 0.001 versus ND group; ## P < 0.01, ### P < 0.001 versus HSD group.


-내장 지방, 피하 지방, 부고환 지방, 신장 지방 등 지방 감소 효과 확인

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Figure 5. Representative adipose tissue staining images in C57BL/6J mice administered with ND, HSD or HSD containing Lb. gasseri BNR17(109 CFU or 1010 CFU) for 10 weeks.


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Figure 6. Adipocyte mean area (㎛2). Data are means ± SD. pairwise t test. ** P < 0.01, *** P < 0.001 versus ND group; ## P < 0.01, ### P < 0.001 versus HSD group.



2) 항당뇨 효과

-BNR17 group 에서 AUC glucose가 현저히 감소

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Figure 7. Oral glucose tolerance of db⁄db mice administered Lactobacillus gasseri BNR17 for 12 weeks. The blood glucose levels were determined at 0, 30, 60, 90 and 120 min. *P<0.05, **P<0.01, ***P<0.001 compared with the value of Control. (▲), control; (□), rosiglitazone; (△), BNR17 (7); (■), BNR17 (8); (●), BNR17 (9); (◇), BNR17 (10).


-BNR17 group 에서 Leptin호르몬이 적게 분비되는 것을 관찰

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Figure 8. Effect of Lb. gasseri BNR17 on the endocrine hormones. C57BL/6J mice were given ND, HSD or HSD containing Lb. gasseri BNR17 (109 CFU or 1010 CFU) for 10 weeks. The serum was obtained by centrifugation of whole blood and analyzed. Data are means ± SD. GIP, glucose-dependent insulinotropic polypeptide; GLP, glucagon-like peptide. Wilcoxon rank sum test. * P < 0.05, ** P < 0.01 versus ND group; # P < 0.05 versus HSD group.